| 1984 | A Nightmare on Elm Street | Glen Lantz | |
| 1985 | Private Resort | Jack Marshall | |
| 1986 | Slow Burn | Donnie Fleischer | |
| 1986 | Platoon | Specialist Gator Lerner | |
| 1990 | Cry-Baby | Wade "Cry-Baby" Walker | |
| 1990 | Edward Scissorhands | Edward Scissorhands | Nominated—Golden Globe Award for Best Actor – Motion Picture Musical or Comedy |
| 1991 | Freddy's Dead: The Final Nightmare | Teen on TV | Cameo (as Oprah Noodlemantra) |
| 1993 | What's Eating Gilbert Grape | Gilbert Grape | |
| 1993 | Benny & Joon | Sam | Nominated—Golden Globe Award for Best Actor – Motion Picture Musical or Comedy |
| 1993 | Arizona Dream | Axel Blackmar | |
| 1994 | Ed Wood | Edward D. Wood, Jr. | London Film Critics Circle Award for Best Actor also for Don Juan DeMarco
Nominated—Chicago Film Critics Association Award for Best Actor
Nominated—Golden Globe Award for Best Actor – Motion Picture Musical or Comedy |
| 1995 | Nick of Time | Gene Watson | |
| 1995 | Dead Man | William Blake | |
| 1995 | Don Juan DeMarco | Don Juan/John R. DeMarco | London Film Critics Circle Award for Best Actor (also for Ed Wood) |
| 1996 | Cannes Man | Himself | |
| 1997 | Donnie Brasco | Donnie Brasco/Joseph D. Pistone | Nominated—Chlotrudis Award for Best Actor |
| 1997 | The Brave | Raphael | Nominated—Best Actor Award (Cannes Film Festival) |
| 1998 | Fear and Loathing in Las Vegas | Raoul Duke | playing Hunter S. Thompson |
| 1998 | L.A. Without a Map | Himself/William Blake | Cameo |
| 1999 | The Ninth Gate | Dean Corso | |
| 1999 | Sleepy Hollow | Ichabod Crane | Nominated—Satellite Award for Best Actor - Motion Picture Musical or Comedy
Nominated—Saturn Award for Best Actor |
| 1999 | The Astronaut's Wife | Spencer Armacost | |
| 2000 | Chocolat | Roux | Nominated—Screen Actors Guild Award for Outstanding Performance by a Cast in a Motion Picture |
| 2000 | Before Night Falls | Lt. Victor, Bon Bon | |
| 2001 | From Hell | Frederick Abberline | Nominated—Saturn Award for Best Actor |
| 2000 | The Man Who Cried | Cesar | (Limited release) |
| 2001 | Blow | George Jung | |
| 2003 | Once Upon a Time in Mexico | Sheldon Sands | Nominated—Satellite Award for Best Supporting Actor – Motion Picture |
| 2003 | Pirates of the Caribbean: The Curse of the Black Pearl | Captain Jack Sparrow | Empire Award for Best Actor
Irish Film Award for Best International Actor
Screen Actors Guild Award for Outstanding Performance by a Male Actor in a Leading Role
Nominated—Academy Award for Best Actor
Nominated—BAFTA Award for Best Actor in a Leading Role
Nominated—Broadcast Film Critics Association Award for Best Actor
Nominated—Chicago Film Critics Association Award for Best Actor
Nominated—Golden Globe Award for Best Actor – Motion Picture Musical or Comedy
Nominated—Online Film Critics Society Award for Best Actor
Nominated—Phoenix Film Critics Society Award for Best Actor
Nominated—Satellite Award for Best Actor – Motion Picture Musical or Comedy
Nominated—Saturn Award for Best Actor
Nominated—Washington D.C. Area Film Critics Association Award for Best Actor |
| 2004 | Happily Ever After | L'inconnu | Cameo |
| 2004 | Finding Neverland | J. M. Barrie | Nominated—Academy Award for Best Actor
Nominated—BAFTA Award for Best Actor in a Leading Role
Nominated—Broadcast Film Critics Association Award for Best Actor
Nominated—Empire Award for Best Actor
Nominated—Golden Globe Award for Best Actor – Motion Picture Drama
Nominated—London Film Critics Circle Award for Best Actor
Nominated—Satellite Award for Best Actor – Motion Picture Drama
Nominated—Saturn Award for Best Actor
Nominated—Screen Actors Guild Award for Outstanding Performance by a Male Actor in a Leading Role
Nominated—Screen Actors Guild Award for Outstanding Performance by a Cast in a Motion Picture |
| 2004 | Secret Window | Mort Rainey | |
| 2004 | The Libertine | John Wilmot, 2nd Earl of Rochester | Nominated—British Independent Film Award for Best Actor |
| 2005 | Charlie and the Chocolate Factory | Willy Wonka | Empire Award for Best Actor
Nominated—Golden Globe Award for Best Actor – Motion Picture Musical or Comedy
Nominated—Irish Film Award for Best International Actor
Nominated—London Film Critics Circle Award for Best Actor |
| 2005 | Corpse Bride | Victor Van Dort | Voice role |
| 2006 | Pirates of the Caribbean: Dead Man's Chest | Captain Jack Sparrow | Empire Award for Best Actor
Nominated—Golden Globe Award for Best Actor – Motion Picture Musical or Comedy
Nominated—National Movie Award for Performance – Male |
| 2007 | Pirates of the Caribbean: At World's End | Captain Jack Sparrow | Kids' Choice Award for Favorite Male Movie Star
MTV Movie Award for Best Comedic Performance
Rembrandt Award for Best International Actor
Nominated—National Movie Award for Best Performance by a Male
Nominated—Teen Choice Award for Best Action Adventure Actor |
| 2007 | Sweeney Todd: The Demon Barber of Fleet Street | Sweeney Todd/Benjamin Barker | Golden Globe Award for Best Actor – Motion Picture Musical or Comedy
National Movie Award for Performance – Male
Nominated—Academy Award for Best Actor
Nominated—Broadcast Film Critics Association Award for Best Actor
Nominated—Broadcast Film Critics Association Award for Best Cast
Nominated—Saturn Award for Best Actor |
| 2009 | Public Enemies | John Dillinger | Nominated—Satellite Award for Best Actor – Motion Picture Drama |
| 2009 | The Imaginarium of Doctor Parnassus | Tony (1st transformation) | Shared role with Colin Farrell and Jude Law after the death of Heath Ledger |
| 2010 | Alice in Wonderland | Mad Hatter | Nominated—Golden Globe Award for Best Actor – Motion Picture Musical or Comedy
Nominated—MTV Movie Award for Global Superstar
Nominated—National Movie Award for Best Performance
Nominated—Teen Choice Award for Best Fantasy Actor |
| 2010 | The Tourist | Frank Tupelo/Alexander Pearce | Teen Choice Award for Choice Movie: Actor Action
Nominated—Golden Globe Award for Best Actor – Motion Picture Musical or Comedy |
| 2011 | Rango | Rango | Voice role
Teen Choice Award for Best Voice Actor
Nominated—People's Choice Award for Favorite Animation Movie Voice |
| 2011 | Pirates of the Caribbean: On Stranger Tides | Captain Jack Sparrow | People Choice Award for Favorite Movie Actor
Nominated—Teen Choice Award for Best Fantasy Actor
Nominated—People's Choice Award for Favorite Ensemble Movie Cast |
| 2011 | The Rum Diary | Paul Kemp | |
| 2011 | Jack & Jill | Himself | Cameo |
| 2012 | 21 Jump Street | Tom Hanson | Cameo
post-production |
| 2012 | Dark Shadows | Barnabas Collins | post-production |
